Rift Valley Fever Vaccine Development, Progress and Constraints
نویسندگان
چکیده
Author affiliations: Author affiliations: Central Veterinary Institute of Wageningen University and Research Centre, Lelystad, the Netherlands (J. Kortekaas, R.J.M. Moormann); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J. Zingeser); Food and Agriculture Organization of the United Nations, Rome, Italy (J. Zingeser, P. de Leeuw, S. de La Rocque); Centre International de Recherche Agronomique pour le Développement , Montpellier, France (S. de La Rocque); International Atomic Energy Agency, Vienna, Austria (H. Unger)
منابع مشابه
Current Status of Rift Valley Fever Vaccine Development
Rift Valley Fever (RVF) is a mosquito-borne zoonotic disease that presents a substantial threat to human and public health. It is caused by Rift Valley fever phlebovirus (RVFV), which belongs to the genus Phlebovirus and the family Phenuiviridae within the order Bunyavirales. The wide distribution of competent vectors in non-endemic areas coupled with global climate change poses a significant t...
متن کاملMutagen-directed attenuation of Rift Valley fever virus as a method for vaccine development.
Serial mutagenesis with 5-fluorouracil has been employed to derive an attenuated strain of Rift Valley fever virus for use as a live virus vaccine.
متن کاملPotency of a thermostabilised chimpanzee adenovirus Rift Valley Fever vaccine in cattle
Development of safe and efficacious vaccines whose potency is unaffected by long-term storage at ambient temperature would obviate major vaccine deployment hurdles and limit wastage associated with breaks in the vaccine cold chain. Here, we evaluated the immunogenicity of a novel chimpanzee adenovirus vectored Rift Valley Fever vaccine (ChAdOx1-GnGc) in cattle, following its thermostabilisation...
متن کاملThe Pathogenesis of Rift Valley Fever
Rift Valley fever (RVF) is an emerging zoonotic disease distributed in sub-Saharan African countries and the Arabian Peninsula. The disease is caused by the Rift Valley fever virus (RVFV) of the family Bunyaviridae and the genus Phlebovirus. The virus is transmitted by mosquitoes, and virus replication in domestic ruminant results in high rates of mortality and abortion. RVFV infection in human...
متن کاملRift Valley Fever in Namibia, 2010
During May-July 2010 in Namibia, outbreaks of Rift Valley fever were reported to the National Veterinary Service. Analysis of animal specimens confirmed virus circulation on 7 farms. Molecular characterization showed that all outbreaks were caused by a strain of Rift Valley fever virus closely related to virus strains responsible for outbreaks in South Africa during 2009-2010.
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